Is obesity caused by a virus?

A researcher at the University of Wisconsin has discovered a virus that causes obesity in chickens. The virus is related to two others known to cause obesity in other animals, and she believes that this might be implicated in human obesity. This has led to a theory that the present obesity epidemic is caused by viruses, an idea the article compares to the revelation that ulcers were caused by bacteria, not stress. It would be stunning if it turned out that you could be vaccinated against obesity.

The theory that viruses could play a part in obesity began a few decades ago when Nikhil Dhurandhar, now at Pennington Biomedical Research Center at LSU, noticed that chickens in India infected with the avian adenovirus SMAM-1 had significantly more fat than non-infected chickens. The discovery was intriguing because the explosion of human obesity, even in poor countries, has led to suspicions that overeating and lack of exercise weren't the only culprits in the rapidly widening human girth. Since then, Ad-36 has been found to be more prevalent in obese humans.

In the current study, Whigham et al. attempted to determine which adenoviruses (in addition to Ad-36 and Ad-5) might be associated with obesity in chickens. The animals were separated into four groups and exposed to either Ad-2, Ad-31, or Ad-37. There was also a control group that was not exposed to any of the viruses. The researchers measured food intake and tracked weight over three weeks before ending the experiment and measuring the chickens' visceral fat, total body fat, serum lipids, and viral antibodies.

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